PittsburghV1, Main, Exploration, bibRecord, 002438

Life stress in adolescence predicts early adult reward-related brain function and alcohol dependence

Identifieur interne : 002438 ( Main/Exploration ); précédent : 002437; suivant : 002439

Life stress in adolescence predicts early adult reward-related brain function and alcohol dependence

Auteurs : Melynda D. Casement [États-Unis] ; Daniel S. Shaw ; Stephanie L. Sitnick ; Samuel C. Musselman ; Erika E. Forbes [États-Unis]

Source :

Social Cognitive and Affective Neuroscience [ 1749-5016 ] ; 2014.

RBID : PMC:4350480

Descripteurs français

KwdFr :
- Adolescent, Alcoolisme (physiopathologie), Alcoolisme (psychologie), Anticipation psychologique, Cortex préfrontal (anatomopathologie), Cortex préfrontal (physiopathologie), Encéphale (physiopathologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Imagerie par résonance magnétique, Jeune adulte, Motivation, Mâle, Nourrisson, Performance psychomotrice, Récompense, Réseau nerveux (physiopathologie), Stress psychologique (psychologie), Utilisation de tabac (psychologie), Vieillissement (psychologie), Études longitudinales.
MESH :
- anatomopathologie : Cortex préfrontal.
- physiopathologie : Alcoolisme, Cortex préfrontal, Encéphale, Réseau nerveux.
- psychologie : Alcoolisme, Stress psychologique, Utilisation de tabac, Vieillissement.
- Adolescent, Anticipation psychologique, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Imagerie par résonance magnétique, Jeune adulte, Motivation, Mâle, Nourrisson, Performance psychomotrice, Récompense, Études longitudinales.

English descriptors

KwdEn :
- Adolescent, Aging (psychology), Alcoholism (physiopathology), Alcoholism (psychology), Anticipation, Psychological, Brain (physiopathology), Child, Child, Preschool, Female, Humans, Infant, Longitudinal Studies, Magnetic Resonance Imaging, Male, Motivation, Nerve Net (physiopathology), Prefrontal Cortex (pathology), Prefrontal Cortex (physiopathology), Psychomotor Performance, Reward, Stress, Psychological (psychology), Tobacco Use (psychology), Young Adult.
MESH :
- pathology : Prefrontal Cortex.
- physiopathology : Alcoholism, Brain, Nerve Net, Prefrontal Cortex.
- psychology : Aging, Alcoholism, Stress, Psychological, Tobacco Use.
- Adolescent, Anticipation, Psychological, Child, Child, Preschool, Female, Humans, Infant, Longitudinal Studies, Magnetic Resonance Imaging, Male, Motivation, Psychomotor Performance, Reward, Young Adult.

Abstract

Stressful life events increase vulnerability to problematic alcohol use, and they may do this by disrupting reward-related neural circuitry. This is particularly relevant for adolescents because alcohol use rises sharply after mid-adolescence and alcohol abuse peaks at age 20. Adolescents also report more stressors compared with children, and neural reward circuitry may be especially vulnerable to stressors during adolescence because of prefrontal cortex remodeling. Using a large sample of male participants in a longitudinal functional magnetic resonance imaging study (N = 157), we evaluated whether cumulative stressful life events between the ages of 15 and 18 were associated with reward-related brain function and problematic alcohol use at age 20 years. Higher cumulative stressful life events during adolescence were associated with decreased response in the medial prefrontal cortex (mPFC) during monetary reward anticipation and following the receipt of monetary rewards. Stress-related decreases in mPFC response during reward anticipation and following rewarding outcomes were associated with the severity of alcohol dependence. Furthermore, mPFC response mediated the association between stressful life events and later symptoms of alcohol dependence. These data are consistent with neurobiological models of addiction that propose that stressors during adolescence increase risk for problematic alcohol use by disrupting reward circuit function.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350480

DOI: 10.1093/scan/nsu061
PubMed: 24795442
PubMed Central: 4350480

Affiliations:

Le document en format XML

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<term>Alcoholism (physiopathology)</term>
<term>Alcoholism (psychology)</term>
<term>Anticipation, Psychological</term>
<term>Brain (physiopathology)</term>
<term>Child</term>
<term>Child, Preschool</term>
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<term>Alcoolisme (physiopathologie)</term>
<term>Alcoolisme (psychologie)</term>
<term>Anticipation psychologique</term>
<term>Cortex préfrontal (anatomopathologie)</term>
<term>Cortex préfrontal (physiopathologie)</term>
<term>Encéphale (physiopathologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Jeune adulte</term>
<term>Motivation</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Performance psychomotrice</term>
<term>Récompense</term>
<term>Réseau nerveux (physiopathologie)</term>
<term>Stress psychologique (psychologie)</term>
<term>Utilisation de tabac (psychologie)</term>
<term>Vieillissement (psychologie)</term>
<term>Études longitudinales</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cortex préfrontal</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prefrontal Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Alcoolisme</term>
<term>Cortex préfrontal</term>
<term>Encéphale</term>
<term>Réseau nerveux</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alcoholism</term>
<term>Brain</term>
<term>Nerve Net</term>
<term>Prefrontal Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Alcoolisme</term>
<term>Stress psychologique</term>
<term>Utilisation de tabac</term>
<term>Vieillissement</term>
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<term>Alcoholism</term>
<term>Stress, Psychological</term>
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<term>Female</term>
<term>Humans</term>
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<term>Anticipation psychologique</term>
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<front><div type="abstract" xml:lang="en"><p>Stressful life events increase vulnerability to problematic alcohol use, and they may do this by disrupting reward-related neural circuitry. This is particularly relevant for adolescents because alcohol use rises sharply after mid-adolescence and alcohol abuse peaks at age 20. Adolescents also report more stressors compared with children, and neural reward circuitry may be especially vulnerable to stressors during adolescence because of prefrontal cortex remodeling. Using a large sample of male participants in a longitudinal functional magnetic resonance imaging study (<italic>N</italic>
 = 157), we evaluated whether cumulative stressful life events between the ages of 15 and 18 were associated with reward-related brain function and problematic alcohol use at age 20 years. Higher cumulative stressful life events during adolescence were associated with decreased response in the medial prefrontal cortex (mPFC) during monetary reward anticipation and following the receipt of monetary rewards. Stress-related decreases in mPFC response during reward anticipation and following rewarding outcomes were associated with the severity of alcohol dependence. Furthermore, mPFC response mediated the association between stressful life events and later symptoms of alcohol dependence. These data are consistent with neurobiological models of addiction that propose that stressors during adolescence increase risk for problematic alcohol use by disrupting reward circuit function.</p>
</div>
</front>
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<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Casement, Melynda D" sort="Casement, Melynda D" uniqKey="Casement M" first="Melynda D." last="Casement">Melynda D. Casement</name>
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Life stress in adolescence predicts early adult reward-related brain function and alcohol dependence

Life stress in adolescence predicts early adult reward-related brain function and alcohol dependence

Source :

Descripteurs français

English descriptors

Abstract

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Le document en format XML

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